In stock
$25.88 USD
Short description


Pharmacokinetics: For pharmacokinetic purposes, each component can be considered separately. Salmeterol: Salmeterol acts locally in the lungs, therefore plasma levels are not an indication of therapeutic effects. Furthermore, there are only limited data on the pharmacokinetics of salmeterol due to the technical difficulty of assaying the active substance in plasma due to the low plasma concentrations at therapeutic doses (approximately 200 pg / ml or less) achieved after inhaled dosing.
Fluticasone propionate:
Absorption: The absolute bioavailability of a single dose of inhaled Fluticasone propionate in healthy subjects varies between approximately 5-11% of the nominal dose depending on the inhalation device used. In patients with asthma or COPD, a lower degree of systemic exposure to inhaled fluticasone propionate has been observed.
Systemic absorption occurs primarily through the lungs and is initially rapid and then prolonged. The remainder of the inhaled dose can be swallowed, but contributes minimally to systemic exposure due to low aqueous solubility and presystemic metabolism, resulting in oral availability of less than 1%. There is a linear increase in systemic exposure with increasing inhaled dose.
Distribution: The disposition of Fluticasone propionate is characterized by a high plasma clearance (1,150 ml / min), a large volume of distribution at steady state (approximately 300 L), and a terminal half-life of approximately 8 hours.
The plasma protein binding is 91%.
Biotransformation: Fluticasone propionate is eliminated very quickly from the systemic circulation. The main pathway is metabolism to an inactive carboxylic acid metabolite, by the enzyme cytochrome P450 CYP3A4. Other unidentified metabolites are also found in faeces.
Elimination: The renal clearance of Fluticasone propionate is negligible. Less than 5% of the dose is excreted in the urine, mainly as metabolites. The main part of the dose is excreted in the faeces as metabolites and unchanged active substance.
Pediatric population: In a population pharmacokinetic analysis using data from 9 different device-controlled clinical trials including 350 asthma patients 4 to 77 years of age (174 patients 4 to 11 years of age), Fluticasone propionate systemic exposure after treatment with Fluticasone / salmeterol 50 µg / 100 µg were observed compared to Fluticasone propionate 100 µg.
Special Populations: Hepatic failure can cause an accumulation of fluticasone propionate and salmeterol in plasma, therefore patients in these groups should be closely monitored. In a population pharmacokinetic analysis using data from 9 controlled clinical studies with different devices (IPS, IDM) that included 350 patients with asthma aged 4 to 77 years (174 patients aged 4 to 11 years), a higher systemic exposure of Fluticasone propionate after treatment with salmeterol / Fluticasone propionate IPS 100/50, compared to Fluticasone propionate IPS 100. Geometric mean ratio [90% CI] for salmeterol / Fluticasone propionate vs comparison of Fluticasone propionate in child and adolescent / adult populations.

What shipping methods do you offer?
Currently there is only one shipping method available: regular airmail delivery (15-24 business days) via Mexican postal service, USPS, CANADA POST, and PARCEL FORCE.

Regular airmail is an inexpensive and reliable option.

Tracking information:
Please note that while regular airmail can also be tracked in most cases, the tracking information is available only on delivery (or attempted delivery) of the order. This allows us to see if your order was delivered successfully, but does not provide real-time delivery details.

What are your shipping rates and policies?
At the moment we offer 1 shipping option:

Regular Airmail Delivery (15-24 business days)
Once your order has been shipped, we will send you an email to notify you that your product has left our facilities. From this point on, your product is only 15-24 business days.

Please note that orders are shipped on business days only (Monday through Friday, excluding holidays).

You can view our shipping rate and other information after selecting a particular product.

Do you ship internationally?
In what currency is my purchase transaction received?
The currency used will be the US dollar.

How will my medication be packaged?
Your order will be properly packaged for your protection in transit to destination.

Where are the medications shipped from?
We ship from our office in Acapulco, Gro. Mexico

Where are the drugs you have to sell made?
Most of the drugs we offer are manufactured in Mexico, some are manufactured in countries such as Germany, England, France and others, all manufactured by large multinational laboratories legally established in Mexico.

What is the expiration date of the medications I receive?
We offer the guarantee that your product will have at least 10 months of use at the time of sale, however most of the drugs we sell have an expiration date greater than 1 to 2 years

What is your return policy?
Read the refund and cancellation policy

We are unable to accept credit or debit card payments as VISA and Mastercard policies (do not allow pharmacies established outside the US to sell drugs to US customers).
How do I place an order?
When you click on an ADD TO CART link, you will be directed to our secure server where you will be registered as our customer. After selecting the required product and its quantity, you will be sent an email with the information of your purchase and the information to make the payment.

What happens once I send my order?
If your payment is received and identified, you will immediately receive an order confirmation email and another email once your order has been shipped.

How do I check the status of my order?
After making your purchase, you will receive an email with your order tracking information. This email contains information about the purchase and a link to the official pages of SEPOMEX, USPS, CANADA POST and PARCEL FORCE.

What is your security and privacy policy?
We are committed to protecting your privacy with the highest level of security possible. All your personal information, including name and address, is encrypted so that it cannot be read as it is transmitted from your computer to our server. We use the Secure Socket Layer (SSL) protocol which enables end-to-end data protection.