Pisalpra is the brand name of a medicine containing the active substance alprazolam. Alprazolam belongs to the group of benzodiazepines that are used to treat nervousness, panic attacks and anxiety disorders caused by stressful situations. It can also be used for the short-term treatment of insomnia. The drug helps to reduce tension and anxiety and maintain a stable emotional state.
Mechanism of action
Alprazolam in Pisalpra works by enhancing the effects of gamma-aminobutyric acid (GABA) in the brain, which helps to reduce nervous agitation and achieve a calming effect.
Dosage
The dosage of Pisalpra 0.25 mg tablets can vary significantly depending on the specific disease and individual characteristics of the patient.
1. Generalized anxiety disorder
The starting dose is usually 0.25 mg two to three times daily.
The dose can be gradually increased to the maximum effective dose, but no more than 4 mg per day.
It is important to assess the patient's response and adapt the dosage individually.
2. Panic disorders
In the case of panic attacks, the dosage may be increased, given the higher need for alprazolam.
The initial dose may be 0.5 mg per day, gradually increasing until the desired effect is achieved.
3. Conditions associated with insomnia
Smaller doses of 0.25 mg before bedtime may be used in the treatment of anxiety-related insomnia.
It is important to keep in mind that benzodiazepines are not recommended for long-term treatment of insomnia due to the risk of habituation and dependence.
4. Special patient categories
In elderly or debilitated patients, as well as in those with impaired hepatic or renal function, the dosage should be reduced. The starting dose may be 0.125 mg twice daily.
Abrupt discontinuation of the drug should be avoided, as this may cause withdrawal symptoms. Dosage selection for Pisalpra medication should be done with the utmost care and strictly under medical supervision. This will ensure maximum effectiveness of treatment with minimal risks to the patient's health.
Contraindications
- Allergic reactions: The drug should not be taken by people with a known allergy to alprazolam or any other components of the drug.
- Narrow angle glaucoma: Alprazolam may increase intraocular pressure, so its use is contraindicated in this condition.
- Severe liver dysfunction: Since alprazolam is metabolized in the liver, its use may be dangerous in cases of severe dysfunction of this organ.
- Myasthenia gravis: Benzodiazepines may increase the symptoms of myasthenia gravis.
- Pregnancy and lactation: Alprazolam may have adverse effects on the fetus and may pass into breast milk.
Side effects
- Sedation: Drowsiness, fatigue and decreased concentration are among the most common side effects, especially at the beginning of treatment and with increasing doses.
- Psychomotor disorders: Disturbance of coordination, dizziness, and confusion may be especially pronounced in elderly patients.
- Dependence and withdrawal syndrome: Prolonged use of the drug may lead to physical and psychological dependence, and sudden withdrawal may cause withdrawal symptoms, including increased anxiety, insomnia and seizures.
- Emotional and behavioral reactions: Depression, mood changes, aggressive behavior, and hallucinations may rarely occur but are serious side effects.
- Gastrointestinal disorders: Nausea, constipation or diarrhea may occur in some patients.
How long does the effect of Pizalpra medicine last?
The effect of taking Pisalpra usually occurs within 30-60 minutes after taking it and may last for several hours, depending on the individual characteristics of the body.
How long does Pisalpra alprazolam stay in the body?
Pisalpra alprazolam, being a drug from the group of benzodiazepines, goes through several stages of metabolism and excretion before being completely eliminated from the body.
Metabolism in the liver: The main route of excretion of alprazolam, the active ingredient in Pisalpra, begins in the liver. Here, the drug undergoes metabolism involving cytochrome P450 enzymes. During metabolism, alprazolam is converted into various metabolites, including alpha-hydroxyalprazolam, which also has some pharmacological activity.
Excretion via the kidneys: After metabolization in the liver, alprazolam breakdown products are excreted predominantly by the kidneys via the urine. Some of the metabolites may also be excreted through the intestine with bile.
Half-life: The half-life of alprazolam in the body is important in understanding the duration of its action. On average, this time ranges from 11 to 16 hours. This means that after this period, half of the drug dose will be eliminated from the body.
Factors affecting the elimination rate
Age of the patient: In elderly patients or people with a slow metabolism, the elimination half-life may be longer.
Liver and kidney function: Abnormalities of these organs may slow down the drug elimination process.
Concomitant use of other drugs: Some drugs may increase or decrease the action of liver enzymes, which also affects the rate of metabolism and excretion of alprazolam.
Interaction of Pisalpra with other medicines
1. Interaction with alcohol
Alcohol significantly enhances the sedative effect of alprazolam, which may lead to increased drowsiness, lethargy and even respiratory depression. Therefore, the combination of alprazolam with alcohol is highly undesirable.
2. Interaction with opioid analgesics
Taking opioid analgesics together with Pisalpra may result in increased sedation, depressed respiratory function, coma or even death.
3. Interaction with other psychotropic drugs
Medications for depression, other tranquilizers, sleeping pills, and antipsychotic medications may increase the sedative effect of alprazolam.
4. Interaction with drugs affecting liver enzymes
Drugs that affect liver enzymes, especially cytochrome P450, may alter the metabolism of alprazolam, affecting its concentration in the blood. Such drugs include some antibiotics, antifungal agents, and antiretroviral drugs.
5. Interaction with drugs affecting the central nervous system
Drugs that inhibit the function of the central nervous system may increase the depressant effect of alprazolam, which increases the risk of side effects.
6. Interactions with herbal and nutritional supplements
Certain herbal preparations and dietary supplements, such as St. John's wort, may affect the metabolism of alprazolam, altering its efficacy and safety.
Pisalpra alprazolam 0.25 mg is an effective treatment for anxiety disorders, but its use requires strict adherence to the doctor's recommendations and caution due to potential side effects and interactions with other drugs. By following all recommendations, you will achieve the desired results and avoid the negative effects of the drug on the body.
What shipping methods do you offer?
Currently there is only one shipping method available: regular airmail delivery (10-12 business days) via Mexican postal service, USPS, CANADA POST, and PARCEL FORCE.
Regular airmail is an inexpensive and reliable option.
Tracking information:
Please note that while regular airmail can also be tracked in most cases, the tracking information is available only on delivery (or attempted delivery) of the order. This allows us to see if your order was delivered successfully, but does not provide real-time delivery details.
What are your shipping rates and policies?
At the moment we offer 1 shipping option:
Regular Airmail Delivery (10-12 business days)
Once your order has been shipped, we will send you an email to notify you that your product has left our facilities. From this point on, your product is only 15-24 business days.
Please note that orders are shipped on business days only (Monday through Friday, excluding holidays).
You can view our shipping rate and other information after selecting a particular product.
Do you ship internationally?
yes
In what currency is my purchase transaction received?
The currency used will be the US dollar.
How will my medication be packaged?
Your order will be properly packaged for your protection in transit to destination.
Where are the medications shipped from?
We ship from our office in Acapulco, Gro. Mexico
Where are the drugs you have to sell made?
Most of the drugs we offer are manufactured in Mexico, some are manufactured in countries such as Germany, England, France and others, all manufactured by large multinational laboratories legally established in Mexico.
What is the expiration date of the medications I receive?
We offer the guarantee that your product will have at least 10 months of use at the time of sale, however most of the drugs we sell have an expiration date greater than 1 to 2 years
What is your return policy?
Read the refund and cancellation policy
We are unable to accept credit or debit card payments as VISA and Mastercard policies (do not allow pharmacies established outside the US to sell drugs to US customers).
How do I place an order?
When you click on an ADD TO CART link, you will be directed to our secure server where you will be registered as our customer. After selecting the required product and its quantity, you will be sent an email with the information of your purchase and the information to make the payment.
What happens once I send my order?
If your payment is received and identified, you will immediately receive an order confirmation email and another email once your order has been shipped.
How do I check the status of my order?
After making your purchase, you will receive an email with your order tracking information. This email contains information about the purchase and a link to the official pages of SEPOMEX, USPS, CANADA POST and PARCEL FORCE.
What is your security and privacy policy?
We are committed to protecting your privacy with the highest level of security possible. All your personal information, including name and address, is encrypted so that it cannot be read as it is transmitted from your computer to our server. We use the Secure Socket Layer (SSL) protocol which enables end-to-end data protection.
