| Mechanism of action: Lorazepam, like benzodiazepines, exerts its effect by binding to specific receptors at various sites in the central nervous system, potentiating effects of synaptic inhibition mediated by gamma-aminobutyric acid. In doses greater than 2 mg, lorazepam not only impairs coordination, but also the speed and accuracy of execution. These effects were maximal at 4 hours or more after dosing. Compared with other benzodiazepines, oral lorazepam 1 mg produced a degree of CNS depression comparable to that produced by diazepam 5 mg. The long duration of effect of lorazepam was correlated with a slow decrease in serum concentration. Absorption: In a study with 6 subjects ingesting 4 mg lorazepam after an overnight fast and up to three hours post-dose, the highest plasma concentrations of lorazepam ranged from 40 to 70 ng/mL, which were achieved from 0.5 to 3.0 hours after dosing. Delay periods were observed in 3 of the 6 subjects, prior to the onset of absorption. In all cases, absorption proceeded as an apparent first-order process, with an absorption half-life of 24.9 minutes. Elimination half-life values ranged from 8.4 to 23.9 hours. The highest concentration was 51.3 ± 5.7 ng/ml, this was reached at 1.7 ± 0.5 hours post-dose. Elimination: Has a dose elimination half-life of 12 to 16 hours. The urinary route of excretion predominates in humans. Distribution: It has a protein binding of 90%, so plasma concentrations are proportional to the amount administered. Metabolism: The main metabolic route is through the divation of glucuronide, being the main metabolite in plasma and urine, not having significant activity on the central nervous system. In plasma, the amounts of unchanged lorazepam and glucuronide are of the same magnitude. No lorazepam conjugates other than gluconic acid have been detected in biological materials. The rapid divation of the essentially inactive and easily excreted water-soluble glucuronide is a common property of Lorazepam and other benzodiazepines. |
What shipping methods do you offer?
Currently there is only one shipping method available: regular airmail delivery (10-12 business days) via Mexican postal service, USPS, CANADA POST, and PARCEL FORCE.
Regular airmail is an inexpensive and reliable option.
Tracking information:
Please note that while regular airmail can also be tracked in most cases, the tracking information is available only on delivery (or attempted delivery) of the order. This allows us to see if your order was delivered successfully, but does not provide real-time delivery details.
What are your shipping rates and policies?
At the moment we offer 1 shipping option:
Regular Airmail Delivery (10-12 business days)
Once your order has been shipped, we will send you an email to notify you that your product has left our facilities. From this point on, your product is only 15-24 business days.
Please note that orders are shipped on business days only (Monday through Friday, excluding holidays).
You can view our shipping rate and other information after selecting a particular product.
Do you ship internationally?
yes
In what currency is my purchase transaction received?
The currency used will be the US dollar.
How will my medication be packaged?
Your order will be properly packaged for your protection in transit to destination.
Where are the medications shipped from?
We ship from our office in Acapulco, Gro. Mexico
Where are the drugs you have to sell made?
Most of the drugs we offer are manufactured in Mexico, some are manufactured in countries such as Germany, England, France and others, all manufactured by large multinational laboratories legally established in Mexico.
What is the expiration date of the medications I receive?
We offer the guarantee that your product will have at least 10 months of use at the time of sale, however most of the drugs we sell have an expiration date greater than 1 to 2 years
What is your return policy?
Read the refund and cancellation policy
We are unable to accept credit or debit card payments as VISA and Mastercard policies (do not allow pharmacies established outside the US to sell drugs to US customers).
How do I place an order?
When you click on an ADD TO CART link, you will be directed to our secure server where you will be registered as our customer. After selecting the required product and its quantity, you will be sent an email with the information of your purchase and the information to make the payment.
What happens once I send my order?
If your payment is received and identified, you will immediately receive an order confirmation email and another email once your order has been shipped.
How do I check the status of my order?
After making your purchase, you will receive an email with your order tracking information. This email contains information about the purchase and a link to the official pages of SEPOMEX, USPS, CANADA POST and PARCEL FORCE.
What is your security and privacy policy?
We are committed to protecting your privacy with the highest level of security possible. All your personal information, including name and address, is encrypted so that it cannot be read as it is transmitted from your computer to our server. We use the Secure Socket Layer (SSL) protocol which enables end-to-end data protection.
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