PHARMACOKINETICS AND PHARMACODYNAMICS:
Pharmacokinetics:
Absorption: After oral administration, NOTIX has a bioavailability of approximately 70% with a maximum plasma concentration between 0.5 and 3 hours.
Distribution: Its pharmacokinetics is linear. Plasma protein binding is approximately 92%. The volume of distribution in adults is 0.54 ± 0.02 L/kg.
Metabolism: Hepatic metabolism of NOTIX produces inactive metabolites that are mainly excreted in the urine. NOTIX is a substrate for the hepatic oxidative microsomal isoenzymes CYP1A2 and CYP2D6.
Elimination: It is eliminated in the form of inactive metabolites (hepatic metabolism), mainly in urine (approximately 60%) and feces (approximately 40%). The plasma elimination half-life is on average 2.4 hours (0.7-3.5 hours).
Special populations: In the elderly subject, a decrease in hepatic clearance is observed. The peak concentration is increased by approximately 50% without significant prolongation of the half-life (3 hours on average). The volume of distribution decreases to 0.34 ± 0.05 L/kg.
In patients with renal failure, whether dialyzed or not, a moderate decrease in renal clearance is observed.
In patients with severe hepatic impairment, the bioavailability of NOTIX is increased. Its clearance is significantly reduced and the elimination half-life is prolonged (approximately 10 hours).
Pharmacodynamics: NOTIX is a hypnotic belonging to the imidazopyridine family. Experimental studies have shown a sedative effect at doses lower than those necessary to obtain anticonvulsant, muscle-relaxing or anxiolytic effects. These effects can be explained by a selective agonist action of the macromolecular GABA-omega receptor complex, modulating the opening of the chloride channel.
NOTIX is preferentially fixed under the omega 1 subtype. NOTIX shortens sleep time, reduces the number of nocturnal awakenings, increases sleep duration and improves its quality. These effects are associated with a characteristic electroencephalographic profile, which differs from that of benzodiazepines. Overnight sleep monitoring studies have shown that NOTIX prolongs phase II, as well as phases III and IV (deep sleep).
At the recommended dose, it does not influence the total duration of paradoxical sleep (REM or rapid eye movements).
What shipping methods do you offer?
Currently there is only one shipping method available: regular airmail delivery (10-12 business days) via Mexican postal service, USPS, CANADA POST, and PARCEL FORCE.
Regular airmail is an inexpensive and reliable option.
Tracking information:
Please note that while regular airmail can also be tracked in most cases, the tracking information is available only on delivery (or attempted delivery) of the order. This allows us to see if your order was delivered successfully, but does not provide real-time delivery details.
What are your shipping rates and policies?
At the moment we offer 1 shipping option:
Regular Airmail Delivery (10-12 business days)
Once your order has been shipped, we will send you an email to notify you that your product has left our facilities. From this point on, your product is only 15-24 business days.
Please note that orders are shipped on business days only (Monday through Friday, excluding holidays).
You can view our shipping rate and other information after selecting a particular product.
Do you ship internationally?
yes
In what currency is my purchase transaction received?
The currency used will be the US dollar.
How will my medication be packaged?
Your order will be properly packaged for your protection in transit to destination.
Where are the medications shipped from?
We ship from our office in Acapulco, Gro. Mexico
Where are the drugs you have to sell made?
Most of the drugs we offer are manufactured in Mexico, some are manufactured in countries such as Germany, England, France and others, all manufactured by large multinational laboratories legally established in Mexico.
What is the expiration date of the medications I receive?
We offer the guarantee that your product will have at least 10 months of use at the time of sale, however most of the drugs we sell have an expiration date greater than 1 to 2 years
What is your return policy?
Read the refund and cancellation policy
We are unable to accept credit or debit card payments as VISA and Mastercard policies (do not allow pharmacies established outside the US to sell drugs to US customers).
How do I place an order?
When you click on an ADD TO CART link, you will be directed to our secure server where you will be registered as our customer. After selecting the required product and its quantity, you will be sent an email with the information of your purchase and the information to make the payment.
What happens once I send my order?
If your payment is received and identified, you will immediately receive an order confirmation email and another email once your order has been shipped.
How do I check the status of my order?
After making your purchase, you will receive an email with your order tracking information. This email contains information about the purchase and a link to the official pages of SEPOMEX, USPS, CANADA POST and PARCEL FORCE.
What is your security and privacy policy?
We are committed to protecting your privacy with the highest level of security possible. All your personal information, including name and address, is encrypted so that it cannot be read as it is transmitted from your computer to our server. We use the Secure Socket Layer (SSL) protocol which enables end-to-end data protection.
