Pharmacokinetic properties: Triazolam is a hypnotic with a short plasma half-life of 1.5 to 5.5 hours. Studies in healthy volunteers at recommended doses four times a day for 7 days revealed that there was no evidence of alterations in systemic bioavailability in the rate of elimination or accumulation.
Peak plasma levels (range 1 to 6 ng/ml) are reached 2 hours after oral administration.
Triazolam and its metabolites, mainly as glucuronide conjugates which are inactive, are excreted primarily in the urine. Only small amounts of intact triazolam appear in the urine. The two conjugated primary metabolites appear in 79.9% of urinary excretion. Urinary excretion appears to be biphasic in relation to the time course. In in vitro studies, even extremely high concentrations of triazolam do not displace bilirubin bound to serum albumin.
Pharmacodynamics: In sleep laboratory studies, HALCION® significantly decreased sleep latency, increased sleep duration, and decreased the number of nocturnal awakenings.
After two weeks of consecutive nocturnal administration, the effects of the drug on the total time awake is diminished and the values recorded in the last third of the night approach baseline levels. On the first and/or second night after discontinuation of the drug, total sleep time, percentage of time spent sleeping, and rate of falling asleep frequently were significantly less than on the nights before the drug. This effect is often called “rebound” insomnia.
The type and duration of hypnotic effects and the profile of undesirable effects during benzodiazepine administration may be influenced by the biological half-life of the administered drug and any active metabolites formed.
When half-lives are long, the drug or its metabolites may accumulate during periods of nocturnal administration and be associated with impairment of cognitive and motor functions during waking hours, the possibility of interaction with other psychoactive drugs or alcohol will be increased. . In contrast, if half-lives are short, drugs and metabolites will be cleared before the next dose is ingested and effects related to excessive sedation or CNS depression should be minimal or absent. However, during nocturnal use for a long period of pharmacodynamic tolerance or adaptation of some hypnotic benzodiazepine effects may develop.
If the drug has a short elimination half-life, it is possible that a relative deficiency of the drug or its active metabolites (e.g., relative to the receptor site) may occur at some point between each nocturnal administration.
This sequence of events may be taken into account for two reported clinical findings that occurred after two weeks of nocturnal administration of rapidly eliminating benzodiazepine hypnotics.
• Increased wakefulness during the last third of the night.
• The presence of anxiety during the day after 10 days of continuous treatment.
What shipping methods do you offer?
Currently there is only one shipping method available: regular airmail delivery (10-12 business days) via Mexican postal service, USPS, CANADA POST, and PARCEL FORCE.
Regular airmail is an inexpensive and reliable option.
Tracking information:
Please note that while regular airmail can also be tracked in most cases, the tracking information is available only on delivery (or attempted delivery) of the order. This allows us to see if your order was delivered successfully, but does not provide real-time delivery details.
What are your shipping rates and policies?
At the moment we offer 1 shipping option:
Regular Airmail Delivery (10-12 business days)
Once your order has been shipped, we will send you an email to notify you that your product has left our facilities. From this point on, your product is only 15-24 business days.
Please note that orders are shipped on business days only (Monday through Friday, excluding holidays).
You can view our shipping rate and other information after selecting a particular product.
Do you ship internationally?
yes
In what currency is my purchase transaction received?
The currency used will be the US dollar.
How will my medication be packaged?
Your order will be properly packaged for your protection in transit to destination.
Where are the medications shipped from?
We ship from our office in Acapulco, Gro. Mexico
Where are the drugs you have to sell made?
Most of the drugs we offer are manufactured in Mexico, some are manufactured in countries such as Germany, England, France and others, all manufactured by large multinational laboratories legally established in Mexico.
What is the expiration date of the medications I receive?
We offer the guarantee that your product will have at least 10 months of use at the time of sale, however most of the drugs we sell have an expiration date greater than 1 to 2 years
What is your return policy?
Read the refund and cancellation policy
We are unable to accept credit or debit card payments as VISA and Mastercard policies (do not allow pharmacies established outside the US to sell drugs to US customers).
How do I place an order?
When you click on an ADD TO CART link, you will be directed to our secure server where you will be registered as our customer. After selecting the required product and its quantity, you will be sent an email with the information of your purchase and the information to make the payment.
What happens once I send my order?
If your payment is received and identified, you will immediately receive an order confirmation email and another email once your order has been shipped.
How do I check the status of my order?
After making your purchase, you will receive an email with your order tracking information. This email contains information about the purchase and a link to the official pages of SEPOMEX, USPS, CANADA POST and PARCEL FORCE.
What is your security and privacy policy?
We are committed to protecting your privacy with the highest level of security possible. All your personal information, including name and address, is encrypted so that it cannot be read as it is transmitted from your computer to our server. We use the Secure Socket Layer (SSL) protocol which enables end-to-end data protection.
