Progesterone is a natural hormone that binds to specific receptors to induce specific progestational effects. As a result of this binding, progesterone is able to interfere with the binding sites of other steroids. Therefore, progesterone exhibits antiestrogenic, antiandrogenic, and also antimineralocorticoid activity.
The mechanism of action of progesterone is similar to that of all steroids at the cellular level. For transport via the blood, it binds to a carrier globulin (SHBG) on specific receptors on target cells such as the female reproductive organs, mammary glands, the central nervous system (including the region of the pulse generator in the hypothalamus), and the pituitary gland. Two types of receptors have been described: alpha and beta, and progesterone binds to the receptor, triggering a stimulus in the phosphorylation cascade mechanism, forming a hormone-receptor (HR) complex. This HR activates the nuclear receptors of nuclear adenyl cyclase, producing dephosphorylation and translocation at the nuclear level, modifying DNA proteins with activation of RNA polymerase, which initiates the transcription phenomenon. Methylation-activated DNA triggers the order for messenger RNA to travel to the ribosomes and produce the desired response.
The absorption of progesterone is much more efficient when it is applied intramuscularly than when it is administered orally. The absorption of progesterone is rapid, so its half-life is only a few minutes.
Absorption: Following intramuscular administration of 10 mg progesterone in oil, peak plasma concentrations (geometric mean of 7 ng/mL) were reached approximately 8 hours after injection and plasma concentrations remained above the upper limit line. base for approximately 24 hours after injection. Injection of 10, 25, and 50 mg resulted in geometric mean maximum plasma concentration (Cmax) values of 7, 28, and 50 ng/mL, respectively.
Distribution: Progesterone is extensively bound to plasma proteins, primarily to albumin (50-54%) and the binding protein cortisol (43-48%).
Metabolism: Progesterone is metabolized primarily in the liver by reducing pregnandiol, pregnanetriol, and pregnanolone. Subsequently as a result formation of glucuronide and sulfate conjugated metabolites. The average plasma metabolic clearance rate in women is 2510 + 135 (wk) L/day.
Excretion: The glucuronide and sulfate conjugated metabolites of pregnandiol and pregnalonone are excreted in the urine and bile. Progesterone metabolites that are excreted in the bile may undergo enterohepatic recirculation or may be excreted in the feces.
A small amount of progesterone is stored in fatty tissue and is released when plasma levels decrease. Although rapidly eliminated if given at daily intervals, it is therapeutically effective. The effects of progesterone in the body continue for several days after the medication is stopped.
The pharmacological effects of progesterone at higher therapeutic doses include suppression of ovulation, preservation of pregnancy by inhibition of uterine contractility, transformation of proliferative endometrium to secretory endometrium.
Renal Insufficiency: Safety and efficacy in patients with renal insufficiency have not been established. Progesterone metabolites are primarily excreted via the kidneys, so progesterone should be administered with caution and careful monitoring in this patient population.
Hepatic insufficiency: Safety and efficacy in patients with hepatic insufficiency have not been established. Since progesterone is metabolized by the liver, use in patients with liver dysfunction or disease is contraindicated.
CUERPO AMARILLO FUERTE
What shipping methods do you offer?
Currently there is only one shipping method available: regular airmail delivery (15-24 business days) via Mexican postal service, USPS, CANADA POST, and PARCEL FORCE.
Regular airmail is an inexpensive and reliable option.
Please note that while regular airmail can also be tracked in most cases, the tracking information is available only on delivery (or attempted delivery) of the order. This allows us to see if your order was delivered successfully, but does not provide real-time delivery details.
What are your shipping rates and policies?
At the moment we offer 1 shipping option:
Regular Airmail Delivery (15-24 business days)
Once your order has been shipped, we will send you an email to notify you that your product has left our facilities. From this point on, your product is only 15-24 business days.
Please note that orders are shipped on business days only (Monday through Friday, excluding holidays).
You can view our shipping rate and other information after selecting a particular product.
Do you ship internationally?
In what currency is my purchase transaction received?
The currency used will be the US dollar.
How will my medication be packaged?
Your order will be properly packaged for your protection in transit to destination.
Where are the medications shipped from?
We ship from our office in Acapulco, Gro. Mexico
Where are the drugs you have to sell made?
Most of the drugs we offer are manufactured in Mexico, some are manufactured in countries such as Germany, England, France and others, all manufactured by large multinational laboratories legally established in Mexico.
What is the expiration date of the medications I receive?
We offer the guarantee that your product will have at least 10 months of use at the time of sale, however most of the drugs we sell have an expiration date greater than 1 to 2 years
What is your return policy?
Read the refund and cancellation policy
We are unable to accept credit or debit card payments as VISA and Mastercard policies (do not allow pharmacies established outside the US to sell drugs to US customers).
How do I place an order?
When you click on an ADD TO CART link, you will be directed to our secure server where you will be registered as our customer. After selecting the required product and its quantity, you will be sent an email with the information of your purchase and the information to make the payment.
What happens once I send my order?
If your payment is received and identified, you will immediately receive an order confirmation email and another email once your order has been shipped.
How do I check the status of my order?
After making your purchase, you will receive an email with your order tracking information. This email contains information about the purchase and a link to the official pages of SEPOMEX, USPS, CANADA POST and PARCEL FORCE.
We are committed to protecting your privacy with the highest level of security possible. All your personal information, including name and address, is encrypted so that it cannot be read as it is transmitted from your computer to our server. We use the Secure Socket Layer (SSL) protocol which enables end-to-end data protection.